antinociceptive effects of oral and intraperitoneal administration of alcoholic datura stramonium seeds extract in male rats

Authors

m khalili

m atyabi

abstract

the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed seeds. then, the animals from each group were subjected to pain scoring experiments such as hot plate and formalin tests. the results of the experiments i.e., antinociceptive effect of ds seeds extract in i.p (5, 10, 25, 50, 100, 200 and 250 mg/kg) and oral application methods (200, 400 and 800 mg/kg) were compared with other groups, morphine sulfate and naloxone as positive and negative control groups, respectively. we found the 30 and 100 mg/kg of the extract as intraperitoneal ed50 in the hot plate and formalin tests, respectively. however, the extract over than 100 mg/kg, i.p could potentially alleviate the pain in hot plate and both phases of formalin test. besides, there was a marked antinociceptive effect for the extract (over than 400 mg/kg) in oral method in hot plate and both phases of formalin tests. in our following experiments the effective doses of morphine sulfate as positive control test were obtained over than 15 mg/kg; i.p. and the acquired ld50 was close to 2300 mg/kg. in summary, comparing the analgesic effect of different doses of morphine sulfate with ds seed extract  in i.p and oral conditions and considering to the extract ld50, we conclude that the ds seeds extract have a potent, absorbable, and nearly safe ingredient which can exert a potential analgesic effect in acute and chronic pain.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Antinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats

The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...

full text

Antinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats

The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...

full text

Antinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats

The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...

full text

Antinociceptive Effect of Oral and Intraperitoneal Administration of Alcoholic Viscum Album Fruit Extract in Male Rats

Objective: The present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic Viscum album (V.A) fruit extract as a rich source of alkaloid substances. Materials and Methods: Experimented animals were divided into control and treatment groups. The treatment rats received different doses of the V.A fruit extract, which was prepared from alcoholic sma...

full text

antinociceptive effect of oral and intraperitoneal administration of alcoholic viscum album fruit extract in male rats

objective: the present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic viscum album (v.a) fruit extract as a rich source of alkaloid substances. materials and methods: experimented animals were divided into control and treatment groups. the treatment rats received different doses of the v.a fruit extract, which was prepared from alcoholic sma...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۲۰۰۴، شماره ۱۰، صفحات ۲۳۱-۲۳۶

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023